Drug Release and Biocompatibility of a Paclitaxel-Coated Balloon Prepared Using the Electrostatic Spray Method

Paclitaxel-coated balloons (PCBs) have become effective treatment options for vascular disease, but long-term drug release and biocompatibility are influenced by the patterns. In this work, paclitaxel coatings were prepared via electrostatic spraying, effect of D-tartaric acid additives was investigated. Microstructures surface morphology studied using Fourier transform infrared spectroscopy (FTIR) scanning electron microscopy (SEM), respectively. Drug measured in vitro, evaluated haemolysis rate, platelet adhesion activation, protein adsorption, cell adhesion, proliferation. Our results showed that a uniform crystalline coating obtained, pattern content D-tartrate. The contact angle all less than nylon 12. at mass ratio to 2:1 had highest brief period time. rate 5%. Compared with control samples, activation significantly reduced, albumin adsorption increased, fibrinogen reduced on coating. Endothelial cells demonstrated good proliferation after three days culture. Therefore, PCBs specific patterns release, potential clinical applications disease.